Clinical Overview
The Reynolds Risk Score was developed to improve cardiovascular risk prediction, particularly in women and individuals whom traditional scores might misclassify as "low risk."
Pathophysiology & Evidence
Systemic inflammation plays a direct role in the destabilization of atherosclerotic plaques. High-sensitivity CRP (hsCRP) is a sensitive biomarker for this vascular inflammation. By integrating hsCRP and genetic predisposition (family history), the Reynolds score successfully reclassifies many intermediate-risk patients into higher or lower risk tiers, allowing for more precise preventative therapy.
Formula Breakdown
Risk = Base Risk + hsCRP Modifier + Family History