Medical Diagnostics & Clinical Scoring

San Francisco Syncope Rule

Apply the San Francisco Syncope Rule to identify patients who are at high risk for serious outcomes within 7 days of a syncopal episode.

Low Risk

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Syncope (fainting) is a common, challenging presentation in the emergency department. While most cases are benign (e.g., vasovagal syncope), a subset of patients have life-threatening underlying causes such as arrhythmias, pulmonary embolism, or internal bleeding. The San Francisco Syncope Rule (SFSR) was developed to help identify these high-risk patients.

The CHESS Criteria

The rule uses the mnemonic CHESS to evaluate the risk of serious outcomes (like death, myocardial infarction, arrhythmia, pulmonary embolism, or significant hemorrhage) within 7 days:

  • Congestive Heart Failure (history of)
  • Hematocrit < 30%
  • ECG abnormality (any non-sinus rhythm or new changes)
  • Shortness of breath (as a symptom associated with the syncope)
  • Systolic Blood Pressure < 90 mmHg at ED triage

CHESS Criteria: High risk if any one of: CHF history, Hematocrit <30%, ECG abnormal, Shortness of breath, Systolic BP <90.

Where:
C=
History of Congestive Heart Failure.
H=
Hematocrit < 30%.
E=
Abnormal ECG.
S=
Shortness of breath.
S (Triage)=
Systolic Blood Pressure < 90 mmHg at triage.

Interpretation

If a patient has any one of the CHESS criteria, they are considered high risk and typically warrant admission or prolonged observation with cardiac monitoring. If they have none, they are lower risk and may be candidates for outpatient follow-up. Note: Subsequent external validation studies of the SFSR have yielded varying sensitivities, leading many clinicians to use it alongside other risk stratification tools (like the OESIL score or clinical gestalt).

Frequently Asked Questions

It is a clinical decision tool designed to identify patients presenting to the emergency department with syncope who are at high risk for serious, potentially life-threatening outcomes within 7 days.

CHESS stands for: Congestive heart failure history, Hematocrit < 30%, ECG abnormalities, Shortness of breath, and Systolic blood pressure < 90 mmHg at triage.

No rule is 100% perfect. While a negative rule indicates a lower risk, subsequent validation studies have shown varied sensitivity. The rule should be used as an adjunct to clinical judgment, not a replacement.